Research Faculty

mini

Mini Jose Deepak

Ramalingaswami Fellow

Phone : +91 80 2293 2518
E-Mail : mini[at]iisc.ac.in

Research Areas

Differentiation of neuronal processes into subtypes


Research Details

Differentiation of neuronal processes into subtypes namely, axons and dendrites remain to be a highly intriguing but critical mechanism for survival during neuronal development.

Interestingly, though different approaches have been adopted to intercept the molecular mechanism behind, a clear model on this critical transition during development remains unclear. In my project, I try to address this interesting question by adopting a multidisciplinary approach combining molecular biology and single molecule based superresolution microscopy to study the role of lipid metabolism in neuronal differentiation using mouse hippocampal neurons as the model system.

Publications

Jose M., Tollis S., Nair D.K., Mitteau R, Velours C, Massoni-Laporte A, Rouyou A, Sibarita J.B., McCusker D, (2015), A quantitative imaging-based screen reveals the exocyst as a network hub connecting endocytosis and exocytosis, Mol Biol Cell, 26(13):2519-34.

Jose M., Tollis S., Nair D.K., Sibarita J.B., McCusker D, (2013), Robust polarity establishment occurs via an endocytosis-based cortical corralling mechanism, J Cell Biol, 200(4): 407-18