Reddy P. KommaddiRamalingaswami Fellow
Phone : +91 80 2293 3432
E-Mail : reddy[at]iisc.ac.in
G-protein coupled receptors
The G-protein coupled receptors are ubiquitously expressed and regulate most physiological processes. GPCRs function through β-arrestin adaptor proteins, which regulate receptor signal transduction and intracellular trafficking. β-arrestin2 ubiquitination promotes GPCR endocytosis and β-arrestin dependent signaling. Ubiquitination of β-arrestin2 and mGluRs may affect the abundance of synaptic proteins and neurotransmitter receptors at the synapse as well as morphological changes of synapse and spines in Alzheimer’s disease.
We are trying to understand how ubiquitination and deubiquitination of mGluRs and β-arrestin2 contribute to the agonist induced synaptic functions in cellular models and mouse models of Alzheimer’s disease.
Our research will provide new insights involving β-arrestin2 and mGluRs ubiquitination for therapeutic intervention and prevention of disease progression.