Early Mechanisms Of Neurodegeneration
Synapses are fundamental to neuronal communication. A major goal of the laboratory is to examine early synaptic changes during the prodromal stages of Alzheimer’s disease. Using primary neuronal cultures and synaptic preparations from mouse models of the disease, we have shown structural and functional deficits in the synapse much before amyloid plaque pathology is observed in these systems. Further, using patient brain tissue, we also demonstrate that these defects are correlated with the extent of the disease.
We are also developing potential therapeutic strategies for Alzheimer’s disease utilizing the extensive knowledge bank of Ayurveda. Through our experiments, we have identified a new peripheral mechanism that reverses brain pathology and behavioral deficits in an animal model.
On the other hand, using cellular and animal models of Parkinson’s disease, we are studying how oxidative stress can trigger specific dopaminergic neuronal death. To delineate underlying pathogenesis, we not only employ classical animal models, but are actively developing novel models of disease as well.
PI : Prof.Vijayalakshmi Ravindranath (Webpage)