Faculty

faculty-aditya

Aditya Murthy

Professor and Chairperson

Office : Ground floor of PRL at Central Animal Facility
Phone : +91 80 2293 3290
E-Mail : adi[at]iisc.ac.in
web : www.cns.iisc.ac.in/aditya/

Research Areas

Brain mechanisms of motor control


Research Details

The brain is the most complex information processing systems known to man and considerable neural machinery is devoted to making visuo-motor tasks such as reaching and grasping seem effortless. Drawing from research in robotics many steps are likely to be involved while planning and executing movements. Some of these stages are decision-making or target selection,coordinate transformations, planning kinematics and dynamics, error correction and performance monitoring. While movements in robots can be superior to naturally occurring movements in terms of speed and accuracy, they are still relatively primitive when it comes to mimicking natural behaviors that occur in unpredictable and unstructured environments.Our lab studies the neural and computationalbasis of movement planning and control with an emphasis to understand the basis of flexibility and control that is the hallmark of intelligent action. From the perspective of behavior we seekto understand the nature of computations that enable motor control; from the perspective of the brain we seek to understand the contribution of circumscribed neural circuits to motor behavior; and by recording the electrical activity of neurons and muscles we seek to understand how such computational processes are implemented by the brain. Our research interests span the fields of visual perception, decision-making, and the generation of motor behavior and involve the application of cognitive/psychophysical,neuropsychological and electrophysiological techniques. We anticipate that in the long term this work will be useful to understand the basis of different motor disorders and develop brain machine interface systems that are only beginning to be exploited as engineering and brain sciences are starting to increasingly interface.

am-research

Publications

Sendnilnathan N., Basu D., and Murthy A., (2017), Simultaneous analysis of the LFP and spiking activity reveals essential components of a visuomotor transformation in the frontal eye field, Proc Natl Acad Sci U S A, 114 (24) : 6370-6375

Bhutani N., Sengupta S., Basu D., Prabhu N. and Murthy A., (2017), Parallel activation of prospective motor plans during the planning of sequential saccades, European Journal of Neuroscience, 45 : 631-642

Pouget P, Murthy A, and Stuphorn V., (2017), Cortical control and performance monitoring of interrupting and redirecting movements, Philosophical Transactions of the Royal Soc., (B) 372: 20160201

Sumitash J, Gopal Atul PA, and Murthy A., (2017), Evidence of common and separate eye and hand accumulators underlying flexible eye-hand coordination, J. Neurophysiology, 117(1) : 348-364

Gopal Atul PA, Jana Sumitash and Murthy A., (2017), Contrasting speed accuracy trade-offs for eye and hand movements reveal the optimal nature of saccade kinematics, J. Neurophysiology , 118(3):1664-1676

Jana Sumitash, and Murthy A, (2017), The Influence of Saccades in Shaping Curved Hand Movement Trajectory, Open Science Framework, osf.io/u3dxc

Varsha V, Radhakant Padhi, Murthy A, (2017), A Stochastic Feedback Model to Simulate Saccadic Eye Movement Variability, IFAC-PapersOnLine, Volume 50, Issue 1,, 13521-13525

Gopal Atul P. and Murthy A., (2016), A common control signal and a ballistic stage can explain the control of coordinated eye-hand movements., J. Neurophysiology , 115(5): 2470-84

Nelson M.J., Murthy A. and Schall J.D., (2016), Neural control of visual search by frontal eye field: Identification of stages of processing and neural accumulation with a race to threshold., J. Neurophysiology , 115(4):, 1954-69

Singh P., Ghosal A. and Murthy A., (2016), Exploration of joint redundancy but not task space variability facilitates supervised motor learning, Proc. Natl Acad. Sci. (USA), 113(50) : 14414-19

Gopal Atul P. and Murthy A., (2015), Eye-hand coordination during a double-step task: evidence for a common stochastic accumulator., J. Neurophysiology

Sharika KM, and Murthy A. , (2015), Contextual modulation during the planning of sequential saccades. Journal of Vision., Journal of Vision. , 113(7):1-18

Gopal Atul PA., Vishwanathan P. and Murthy A., (2015), A common stochastic accumulator with effector-dependent noise can explain eye-hand coordination.J. Neurophysiology, .J. Neurophysiology 113(7), 113(7):2033-48

Sharika KM, Ramakrishnan, A. and Murthy A., (2014), Use of exocentric and egocentric representations in the concurrent planning of sequential saccades., Journal of Neuroscience , 34:16009-21.

Bhutani N, Sureshbabu Ramakrishnan, A. Farooqui A, Behari M, Goyal V, and Murthy A. , (2013), Queuing of concurrent movement plans by basal ganglia., Journal of Neuroscience , 33(24): 9985-97

Ramakrishnan, A. and Murthy A. , (2013), Brain Mechanisms for decision-making and motor control., Progress in Brain Research, 202:321-45

Sharika KM, Neggers SF, Gutteling TP, Van der Stigchel S, Dijkerman HC, Murthy A., (2013), Proactive control of sequential saccades in human supplementary eye field., Proc Natl Acad Sci U S A. , 110(14):1311-20

Bhutani N, Ray S, and Murthy A., (2012), Is saccade averaging determined by visual processing or movement planning?, J. Neurophysiology., 108: 3161-3171

Ray S., Bhutani N and Murthy A., (2012), Mutual inhibition and capacity sharing during parallel preparation of serial eye movements., Journal of Vision., 12(3)17:1-22

Ramakrishnan, A., Sureshbabu Ramakrishnan and Murthy A., (2012), Understanding how the brain changes its mind: microstimulation in the macaque frontal eye field reveals how saccade plans are changed., Journal of Neuroscience., 32(13) : 4457- 4472

Ray S., Bhutani N., V. Kapoor and Murthy A., (2011), Trans-saccadic integration of visual and motor processing during sequential eye movements., Experimental Brain Research, 215 : 13-25

Farooqui AA, Bhutani N, Kulashekhar S, Behari M, Goel V, Murthy A., (2011), Impaired conflict monitoring in Parkinson’s disease patients during an oculomotor redirect task, Exp Brain Res., 208(1) : 1-10

Ramakrishnan A, Chokhandre S, Murthy A., (2010), Voluntary control of multi-saccade gaze shifts during movement preparation and execution, J. Neurophysiology, 103 : 2400-16

Murthy A, Ray S, Shorter SM, Schall JD,Thompson KG, (2009), Neural Control of Visual Search by Frontal Eye Field: Effects of Unexpected Target Displacement on Visual Selection and Saccade Preparation, J. Neurophysiology, 101: , 2485-2507

K.M. Sharika, Supriya Ray and Murthy A., (2009), Attention for Action during Error Correction, Progress in Brain Research, 176: , 227-244