Prof. Vijayalakshmi Ravindranath
Professor,
Centre for Neuroscience,
IISc

The unifying goal of the laboratory is to understand pathogenic mechanisms underlying neurodegenerative disorders that would potentially lead to identification of drug targets that can be used to develop rational disease modifying therapies. To this effect, we adopt a combinatorial approach involving biochemical and histochemical techniques to elucidate pathogenically important cellular pathways in animal models of Parkinson's and Alzheimer's disease. From the therapeutic angle, we are also defining the mode of action of traditional medicinal preparations used in the treatment of neurodegenerative disorders, particularly senile dementia, which help us to screen natural products that can be developed as potential drugs. Drug targets alone do not ensure successful therapeutic strategies, as in situ drug metabolism in the brain is critical for drug action. In this regard, we are identifying and characterizing brain CYP450 enzymes with particular emphasis on brain-specific biotransformation pathways of both drugs and endogenous compounds that play a role in pathogenic phenomena, such as inflammation in the brain.

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