Prof. Vijayalakshmi Ravindranath
Chairperson,
Centre for Neuroscience,
IISc
  • Ahmad F, Singh K, Das D, Gowaikar R, Shaw E, Ramachandran A, Rupanagudi KV, Kommaddi RP, Bennett DA, Ravindranath V. ABeta mediates F-actin disassembly in dendritic spines leading to cognitive deficits in Alzheimer's disease, 2018 J Neuroscience.

  • Ahmad F, Singh K, Das D, Gowaikar R, Shaw E, Ramachandran A, Rupanagudi KV, Kommaddi RP, Bennett DA, Ravindranath V. Reactive Oxygen Species-Mediated Loss of Synaptic Akt1 Signaling Leads to Deficient Activity-Dependent Protein Translation Early in Alzheimer's Disease, 2017 Antioxid Redox Signal. [Pubmed abstract]   [Cover image]

  • Saykally JN, Hatic H, Keeley KL, Jain S, Ravindranath V. Citron BA: Withaniasomnifera Extract Protects Model Neurons from In Vitro Traumatic Injury. Cell Transplant. doi: 10.3727/096368916X693770

  • Ray A, Kambali M, Ravindranath V. Thiol Oxidation by Diamide Leads to Dopaminergic Degeneration and Parkinsonism Phenotype in Mice: A Model for Parkinson's Disease, 2016 AntioxidRedox Signal. 10;25(5):252-67

  • Ray A, Sehgal N, Karunakaran S, Rangarajan G, Ravindranath V. MPTP activates ASK1-p38 MAPK signaling pathway through TNF-dependent Trx1 oxidation in parkinsonism mouse model. Free Radic Biol Med. 2015 Oct;87:312-25. [Pubmed abstract]

  • Ravindranath V, Dang HM, Goya RG, Mansour H, Nimgaonkar VL, Russell VA, Xin Y. Regional research priorities in brain and nervous system disorders. Nature. 2015 527(7578):S198-206[Pubmed abstract]

  • Ahmad F, Nidadavolu P, Durgadoss L, Ravindranath V. Critical cysteines in Akt1 regulate its activity and proteasomal degradation: implications for neurodegenerative diseases. Free Radic Biol Med. 2014 Sep;74:118-28. [Pubmed abstract]

  • Ravindranath V and Strobel H.W. Cytochrome P450-mediated metabolism in brain: functional roles and their implications. Expert Opin Drug Metab Toxicol. 2013 9: 551-558 [Pubmed abstract]

  • Sehgal N., Gupta, A., Khader Valli, R., Shanker Datt Joshi, Jessica T. Mills, Edith Hamel, Khanna, P., Jain, S. C., Thakur, S.S. and Ravindranath V. Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver. Proc. Natl. Acad. Sci. USA 109: 3510-5, 2012.[Full Text]

  • Saeed U, Ray A, Valli RK, Kumar AM, Ravindranath V. DJ-1 Loss by Glutaredoxin But Not Glutathione Depletion Triggers Daxx Translocation and Cell Death.Antioxid Redox Signal. 2010 Mar 4.[Pubmed abstract]

  • Saeed U, Karunakaran S, Meka DP, Koumar RC, Ramakrishnan S, Joshi SD, Nidadavolu P, Ravindranath V. Redox activated MAP kinase death signaling cascade initiated by ASK1 is not activated in female mice following MPTP: novel mechanism of neuroprotection. Neurotox Res. 2009 Aug;16(2):116-26. Epub 2009 May 1.[Pubmed abstract]

  • Karunakaran S, Ravindranath V. Activation of p38 MAPK in the substantia nigra leads to nuclear translocation of NF-kappaB in MPTP-treated mice: implication in Parkinson's disease. J Neurochem. 2009 Jun;109(6):1791-9. Epub 2009 May 11.[Pubmed abstract]

  • Karunakaran S, Saeed U, Mishra M, Valli RK, Joshi SD, Meka DP, Seth P, Ravindranath V. Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice. J Neurosci. 2008 Nov 19;28(47):12500-9.[Pubmed abstract]

  • Saeed U, Durgadoss L, Valli RK, Joshi DC, Joshi PG and Ravindranath V. Knockdown of Cytosolic Glutaredoxin 1 Leads to Loss of Mitochondrial Membrane Potential: Implication in Neurodegenerative Diseases: PLoS One. 2008 June; 3(6) [Full Text]

  • Agarwal V, Kommaddi RP, Valli K, Ryder D, Hyde TM, Kleinman JE, Strobel HW and Ravindranath V. Drug Metabolism in Human Brain: High Levels of Cytochrome P4503A43 in Brain and Metabolism of Anti-anxiety Drug Alprazolam to its Active Metabolite. PLoS One. 2008 June; 3(6)
    [Pubmed abstract] [Full Text]
     
  • Karunakaran S, Saeed U, Ramakrishnan S, Kumar RC, Ravindranath V. Constitutive expression and functional characterization of mitochondrial glutaredoxin (Grx2) in mouse and human brain.  Brain Research 2007 Dec 14; 1185:8-17. [Pubmed abstract] [Full Text]
     
  • Kommaddi RP, Turman CM, Moorthy B, Wang L, Strobel HW, Ravindranath V. An alternatively spliced cytochrome P4501A1 in human brain fails to bioactivate polycyclic aromatic hydrocarbons to DNA-reactive metabolites. J Neurochem. 2007 Aug; 102(3): 867-77. [Pubmed abstract] [Full Text]
     
  • Diwakar L, Kenchappa RS, Annepu J, Ravindranath V. Downregulation of glutaredoxin but not glutathione loss leads to mitochondrial dysfunction in female mice CNS: implications in excitotoxicity. Neurochem Int. 2007 Jul; 51(1): 37-46. [Pubmed abstract] [Full Text]
     
  • Karunakaran S, Diwakar L, Saeed U, Agarwal V, Ramakrishnan S, Iyengar S, and Ravindranath V. Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death-associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinson’s disease: protection by α-lipoic acid. FASEB J. 2007 Jul; 21(9): 2226-36. [Pubmed abstract] [Full Text]
     
  • Diwakar L, Ravindranath V. Inhibition of cystathionine-gamma-lyase leads to loss of glutathione and aggravation of mitochondrial dysfunction mediated by excitatory amino acid in the CNS. Neurochem Int. 2007 Jan; 50(2): 418-26. [Pubmed abstract] [Full Text]
     
  • Diwakar L, Kenchappa RS, Annepu J, Saeed U, Sujanitha R, Ravindranath V. Down-regulation of glutaredoxin by estrogen receptor antagonist renders female mice susceptible to excitatory amino acid mediated complex I inhibition in CNS. Brain Res. 2006 Dec 13; 1125(1): 176-84
    [Pubmed abstract] [Full Text]
     
  • Chinta SJ, Kommaddi RP, Turman CM, Strobel HW, Ravindranath V. Constitutive expression and localization of cytochrome P-450 1A1 in rat and human brain: presence of a splice variant form in human brain.J Neurochem. 2005 May; 93(3): 724-36. [Pubmed abstract] [Full Text]
     
  • Kenchappa RS, Diwakar L, Annepu J, Ravindranath V. Estrogen and neuroprotection: higher constitutive expression of glutaredoxin in female mice offers protection against MPTP-mediated neurodegeneration.FASEB J. 2004 Jul;18(10):1102-4. [Pubmed abstract] [Full Text]

Link to PubMed for all publications

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